Protection of Cattle against Rinderpest by Vaccination with Wild-Type Peste des Petits Ruminants Virus

Although rinderpest virus (RPV) has been eradicated in the wild, efforts are still continuing to restrict the extent to which live virus is distributed in facilities around the world and to prepare for any reappearance of the disease, whether through deliberate or accidental release. In an effort to find an alternative vaccine which could be used in place of the traditional live attenuated RPV strains, we have determined whether cattle can be protected from rinderpest by inoculation with vaccine strains of the related morbillivirus, peste des petits ruminants virus (PPRV). Cattle were vaccinated with wild-type PPRV or either of two established PPRV vaccine strains, Nigeria/75/1 or Sungri/96. All animals developed antibody and T cell immune responses to the inoculated PPRV. However, only the animals given wild-type PPRV were protected from RPV challenge. Animals given PPRV/Sungri/96 were only partially protected, and animals given PPRV/Nigeria/75/1 showed no protection against RPV challenge. While sera from animals vaccinated with the vaccine strain of RPV showed cross-neutralizing ability against PPRV, none of the sera from animals vaccinated with any strain of PPRV was able to neutralize RPV although sera from animals inoculated with wild-type PPRV were able to neutralize RPV-pseudotyped vesicular stomatitis virus.

Sourced through Scoop.it from: jvi.asm.org

I have written before in ViroBlogy about the eradication of rinderpest, and what a big deal that was – and here are people taking the gloomy view of wanting to have vaccines against it in case it gets used as a bioweapon, or escapes from fridges or freezers somewhere.

Not that these concerns aren’t valid – but surely it would be a better idea to use recombinant viruses expressing rinderpest envelope glycoproteins, rather than another live virus related to rinderpest which needs to be eradicated itself?
Just asking – but a recombinant poxvirus would seem to me to be a MUCH better option!

See on Scoop.itVirology News

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