Archive for January, 2014

Legends of Virology

31 January, 2014

I have been fortunate enough this week to be in Pretoria, at the first Animal and Human Vaccine Development in South Africa Conference (Twitter #AHVDSA): partly because it is a very timeous and necessary meeting to help to establish strategies for this purpose, and partly because there is a significant presence of some legendary figures of international and South African virology.

Marc van Regenmortel – who we count as local even if he lives in Strasbourg – helped Bob Millar and others at the University of Pretoria to organise this meeting. He also used the opportunity of having a bunch of old virological friends visiting him at the University of Stellenbosch’s STIAS to bolster the conference presentations.

So it was that we have Errling Norrby of Sweden with us; we have Fred Murphy of Ebola fame; Marian Horzinek of veterinary virology repute; Marc himself, our iconoclastic viral immunologist; Jose Esparza of the BMG and an eminent poxvirologist – and Jean-Marie Andrieu, an oncologist with an interest in tolerogenic HIV vaccines.

Local legends are present too: we have Daan Verwoerd, legendary orbivirologist and former Director of the venerable and distinguished Onderstepoort Veterinary Institute; Henk Huismans, who did the first molecular work on orbiviruses in the 1970s, and is still active; Bob Swanepoel, doyen of the African haemorrhagic fever viruses.

Good people.

Oh, and of course, me and Anna-Lise Williamson; Dion du Plessis of OVI; Lynn Morris of the NICD; Albie van Dijk of UNW; Glenda Gray of the MRC, among 150 delegates

A great meeting, all in all, and very timely, given the contents of the SA Governmental Bioeconomy Strategy document released recently.

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Legends alive: from left, Fred Murphy; Daan Verwoerd; Bob Millar; Henk Huismans; Errling Norrby; Marc van Regenmortel
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Jean-Marie Andrieu; Marc van Regenmortel – at a VERY good unofficial dinner

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Legends and friends at supper: Marc, Fred, Eric Etter (CIRAD); Jose Esparza; Marian Horzinek; Errling, Anna-Lise Williamson

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Biodiversity: So much more than legs and leaves

28 January, 2014

See on Scoop.itAquatic Viruses

Microorganisms inhabit virtually every possible niche on Earth, including those at the outer envelope of survival. However, the focus of most conservation authorities and ecologists is the ‘legs and leaves’ side of biology -the ‘macrobiology’ that can be seen with the naked eye. There is little apparent concern for the preservation of microbial diversity, or of unique microbial habitats. Here we show examples of the astounding microbial diversity supported by South Africa’s ecosystems and argue that because microbes constitute the vast majority of our planet’s species they should be considered seriously in the future protection of our genetic resources.

 

Ed Rybicki‘s insight:

This is our stab at getting South African science funders to take microbial diversity seriously.  I helped write it, obviously.  And it’s Open Access!

See on www.scielo.org.za

RNA’s Secret Life Outside the Cell – Wired Science

21 January, 2014

See on Scoop.itVirology News

Circulating RNAs carry messages between the cells of plants and invertebrates. Do they do the same for us?

See on www.wired.com

PCR: Past, Present, & Future

20 January, 2014

See on Scoop.itVirology News

The Scientist, in collaboration with Biosearch Technologies, invited Kary Mullis to reflect back on these 30 years in terms of his initial discovery, how things stand today, and where he thinks PCR is headed in the future.

Ed Rybicki‘s insight:

I got into PCR sometime in around 1988 – and have since developed amplifications for multicopy genes, virus genes, whole virus genomes, and taught students to do the same.  I have worked with papillomaviruses, HIV, geminiviruses, chicken infectious anaemia virus and potyviruses; my students do PCR for gene assembly and verification of cloned inserts, and do quantitative PCR and cDNA PCR for quantitation of gene expression and assay of virus replication in the presence of inhibitory constructs.

It revolutionised our work more than 30 years ago, and continues to be a fundamental workhorse technique in our labs today.

Viva, PCR, viva!

Kary Mullis – not so much.  The man’s a HIV denialist, or has been, and I have no time for them.

See on

New HIV report finds big drop in new HIV infections in South Africa

19 January, 2014

See on Scoop.itVirology News

New data show that new HIV infections have been reduced by about a third from 2004 and 2012. The South Africa 2012 HIV Estimates and Projections at-a-glance report was launched in Durban, South Africa on 10 January by the Deputy President of South Africa, Kgalema Motlanthe and UNAIDS Executive Director, Michel Sidibé. Additionally, the Premier of KwaZulu-Natal, Senzo Mchunu launched the Operation Sukuma Sakhe Best Practices Publication at the same event.

There are 6.1 million people living with HIV in South Africa. Since 2009, the government has massively scaled up HIV prevention and treatment programmes. According to the National Department of Health, in 2012, some 2.2 million people were accessing HIV treatment, making it the largest HIV treatment programme in the world. The data show that the number of new HIV infections has dropped from 540 000 new infections in 2004 to 370 000 in 2012.

Ed Rybicki‘s insight:

At last!  We may have passed the peak of the HIV pandemic – at least in SA – at last!!

It’s been a hard road: denialism, activism, the biggest roll-out of ARVs in the world, socially engineering a whole population to change their behaviour – and maybe it’s finally working!

South Africa needs a "viva!"!!

But we’ve still got 6 million-odd people infected with HIV – and they will be around for a while.  Time for therapeutic vaccines!!

See on www.unaids.org

SOUTH AFRICAN SCHOOL GIRLS TO BE IMMUNISED AGAINST HPV

19 January, 2014

See on Scoop.itVirology News

PRETORIA, Jan 19 (NNN-SANEWS) — Primary school girls in South Africa will from this year be immunised against the Human Papilloma Virus (HPV), which causes cervical cancer.

Announcing its launch at Ngidini Primary School in Libode in the Eastern Cape, President Jacob Zuma said government will target girls aged between nine and 12 years of age, through the Integrated School Health Programme.

“The Departments of Basic Education and Health will work closely together in this national programme to protect our girls from this disease.

“Vaccination teams from the Department of Health will visit schools twice a year to ensure that each girl-child receives two doses of the HPV vaccine. We urge parents to cooperate with us and help us succeed in fighting cervical cancer,” said President Zuma.

Cervical cancer graphic by Russell Kightley Media

Ed Rybicki‘s insight:

At last!  South Africa will finally make HPV vaccines available for free to schoolgirls between 9-12 – in preparation for their eventual exposure, via sex, to the viruses that cause cervical cancer.

HPV vaccines are blockbusters for a reason: they are one of only two viral vaccines that will almost certainly prevent cancer developing in a proportion of those who get infected with the viruses in question – which are, of course, HPV and hepatitis B.

And given that most humans have sex, a pretty high percentage of sexually active humans will be exposed to HPV and – to a lesser extent – HBV.

Sex is a normal activity.  Vaccinating against sexually transmitted diseases is therefore a sensible thing to do.  Vaccinating against HPV in a country where over 12% of the population have HIV, is even more sensible – because HIV worsens the effects of HPV.

Vaccination: the sensible thing to do.

See on www.namnewsnetwork.org

Motsoaledi: Big pharma’s ‘satanic’ plot is genocide

17 January, 2014

See on Scoop.itVirology News

Health minister Aaron Motsoaledi is livid about a pharmaceutical company campaign he says will restrict access to crucial drugs.

Ed Rybicki‘s insight:

Interesting…as an inventor named on a bunch of patents, I should be concerned – but I’m not, because I also believe that people shouldn’t die for want of affordable drugs.

I really, really do.

We have negotiated terms on every licencing deal we have been involved in, that would allow us exclusivity in the African and sometimes other developing world markets – with the intention of ensuring that prices of our product(s) (if any EVER get to market) remain affordable in these regions.

As it is, what the legislation intends to do is to make it more difficult for Big Pharma to extend their patent protection on drugs by simply making changes to formulations, which is a common practice.  I note India is doing the same, and for the same reasons.

Seriously: while companies should receive financial reward for developing drugs, this should not be allowed to continue in perpetuity.

I also don’t think they should be allowed to gouge the market, but that’s another argument.

See on mg.co.za

South Africa’s HIV treatment plan in disarray

8 January, 2014

See on Scoop.itVirology News

South Africa’s HIV/Aids treatment programme is in a state of disarray, and could result in the deaths of thousands of people dependent on it for life-prolonging drugs.

Ed Rybicki‘s insight:

This is actually unconscionable: given that SA was doing so well, with the largest number of people in any country on ARVs, to fail them now is to completely discredit our health system – and our government.

Seriously: why do we have a problem?  First, failures in local and national government; second, indefensible behaviour by local government and others in intimidating whistle-blowers, rather than dealing with the problem at hand.

See on www.health24.com

Doctors baffled about why H1N1 targets young, healthy adults

8 January, 2014

See on Scoop.itVirology News

News that most of the 10 people in Alberta who’ve died from the flu were young, healthy adults has many concerned about who is at risk.

Ed Rybicki‘s insight:

Isn’t that exactly what happened in the pandemic in 2009 – and in 1918?  A disproportionate number of young healthy adults dying, compared to babies and old folk?

I blogged about this during the pandemic (https://rybicki.wordpress.com/2009/09/14/ah1n1-2009-gets-to-parts-the-other-flu-doesnt-reach/) and noted somewhere (that I can’t find) that the death toll was about as high as normal seasonal flu – but WITHOUT people over 50, who seemed to be protected by prior exposure.

This is a nasty virus: if I weren’t protected by prior exposure – being over 50, I would be worried enough to be vaccinated against it specifically.  So should you be!

See on globalnews.ca

HPV Vaccine: The Earlier, the Better

8 January, 2014

See on Scoop.itVirology News

HPV Vaccine: The Earlier, the Better. HPV Vaccine: The Earlier, the Better

Women who were 18 and up or had abnormal cervical cytology when vaccinated against human papillomavirus (HPV) subsequently had rates ofCervical dysplasiasimilar to those of unvaccinated women, Canadian investigators reported.

Women ≥18 without cervical abnormalities at vaccination had a 23% reduction in the risk of high-grade squamous intraepithelial lesions (HSIL) as compared with unvaccinated women. The quadrivalent vaccine did not appear to protect against HSIL among women who had abnormal cytology at the time they were vaccinated, they reported online in the Journal of Clinical Oncology.

Read more:HPV Vaccine: The Earlier, the Better -Gynecology news –http://www.health.am/gyneco/more/hpv-vaccine-the-earlier-the-better/#ixzz2pnmaeo3A

Ed Rybicki‘s insight:

Yup!  The wait-and-see brigade who say there’s no evidence the vaccine(s) prevent cancer should really shut up: successfully preventing the precursor stages of cervical disease that have been shown to lead to cancer MUST be evidence enough – surely?

See on www.health.am